3 edition of Tissue specific gene expression found in the catalog.
Tissue specific gene expression
Includes bibliographical references.
|Statement||edited by Rainer Renkawitz.|
|LC Classifications||QH450 .T57 1989|
|The Physical Object|
|Pagination||xvii, 221 p. :|
|Number of Pages||221|
|LC Control Number||89016997|
Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene. Gene silencing can occur during either transcription or translation and is often used in research. In particular, methods used to silence genes are being increasingly used to produce therapeutics to combat cancer and other diseases, such as infectious diseases and neurodegenerative disorders. The third class is the tissue-specific genes that consist of two major subclasses; the tissue-enriched genes with at least fivefold higher expression in a specified tissue as compared with all other tissues and the group-enriched genes with at least fivefold higher expression in a small group of tissues as compared with all other by:
Many enhancer elements in higher eukaryotes activate transcription in a tissue-specific manner—that is, they induce expression of a gene in one or a few cell types. For example, antibody genes are flanked by powerful enhancers that operate only in the B lymphocytes of the immune : Anthony Jf Griffiths, William M Gelbart, Jeffrey H Miller, Richard C Lewontin. A conditional RUdependent elav-GAL4 (GeneSwitch) (Osterwalder et al., ) was employed to induce tissue-specific expression of uex in PRL-1 mutants. As RU was fed to the newly hatched.
We first collected 8, TissGenes across 22 tissue types, which are matched with the 28 cancer types of The Cancer Genome Atlas (TCGA) project, from three representative tissue-specific gene expression resources: The Human Protein Atlas (HPA), tissue-specific gene expression and regulation (TiGER), and Genotype-Tissue Expression (GTEx). Background: Tissue specific promoters may be utilized for a variety of applications, including programmed gene expression in cell types, tissues and organs of interest, for developing different cell culture models or for use in gene therapy. We report a novel, tissue-specific promoter that was identified and engineered from the native upstream Cited by:
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To identify tissue-specific network nodes, we compared the median expression level (e j (t)) of a gene (j) in a particular tissue (t) to the median and IQR of its expression across all samples: (Equation 4) s j (t) = (m e d (e j (t)) − m e d (e j (a l l))) / I Q R (e j (a l l)).Cited by: Tissue specific gene expression - a summary, E.J.W.
Winnacker; chromatin remodeling during immunoglobulin gene activation, d; octamer transcription factors mediate B-cell specific expression of immunoglobulin heavy chain genes, ber et al; positive and negative factors contribute to the tissue-specific activities of the immunoglobulin heavy-chain and polyoma-virus.
Interestingly, the system utilized by the cell to ensure tissue specific gene expression is rather simple. Among other factors - all discussed fully in the lesson - the cells make use of a tiny scaffold known as the “Nuclear Matrix or Nucleo-Skeleton”.
Offers information for tissue-specific genes, transcription factors (TFs) and cis-regulatory modules (CRMs) for 30 human tissues. TiGER provides a web browser that allows users to display or download information.
It employs a method based on patterns of co-occurrence of pairs of DNA binding sites to detect interacting TFs. This database can be used to construct plots of gene expression ative name: Tissue-specific Gene Expression and Regulation. Tissue-specific changes induced by RU in a stock-dependent manner.
a Treatment with µM RU induces changes in gene expression in thoraces (consisting primarily of skeletal muscle Cited by: 1. Tissue-specific expression patterns of proteins are more likely to be conserved between pea and Arabidopsis, so we could take advantage of the available quantitative root proteomic and transcriptomic data of Arabidopsis to perform our systematic analyses.
This software characterizes genes by finding out where (tissue specific gene expression profile), when and in response to what they are expressed. You cloud integrating and comparing them with public datasets,and also discover and prioritize your biomarkers according to your a specific tissue gene expression profile.
Tissue-specific patterns of gene expression are fundamental to establishing and preserving tissue identity and function, and dysregulation of these patterns underlies a Cited by: 1.
Andreas E. Voloudakis, N. Beachy, in Gene Expression Systems, Tissue-Specific Promoters. For Specific applications, tissue-specific promoters are available and can be used instead of constitutive promoters. For example, a seed-specific promoter should be employed to change fatty acid synthesis pathways in oil seeds (see later).
Understanding gene regulation is important for many fields in biology and medicine. Sonawane et al. reconstruct and investigate regulatory networks for 38 human tissues.
They find that regulation of tissue-specific function is largely independent of transcription factor expression and that tissue specificity appears to be mediated by tissue-specific regulatory network by: Buy Tissue Specific Gene Expression on FREE SHIPPING on qualified orders Tissue Specific Gene Expression: Renkawitz, Rainer: : Books Cited by: 2.
Cell Reports Article Understanding Tissue-Speciﬁc Gene Regulation Abhijeet Rajendra Sonawane,1,2 John Platig,3,4 Maud Fagny,3,4 Cho-Yi Chen,3,4 Joseph Nathaniel Paulson,3,4 Camila Miranda Lopes-Ramos,3,4 Dawn Lisa DeMeo,1,2,5 John Quackenbush,1,2,3,4,6 Kimberly Glass,1,2,7,8,* and Marieke Lydia Kuijjer3,4 7 * 1Channing Division of Network Medicine, Brigham and Women’s Hospital.
Maize transcription factors show tissue-specific expression patterns. Previously, we re-analyzed high-quality RNA-Seq libraries in various maize tissues and generated a gene coexpression network .Tissues with more than libraries from that expression matrix were chosen to construct tissue-specific GRNs (Fig.
1a).There were four tissues included: leaf, root, shoot apical Cited by: In this study, we applied computational methods to identify tissue-specific splicing factor gene expression signatures from published microarray data sets. By using this approach we have identified over splicing-related genes that are most highly differentially expressed in a particular tissue or differentiation by: Tissue specific promoters may be utilized for a variety of applications, including programmed gene expression in cell types, tissues and organs of interest, for developing different cell culture models or for use in gene therapy.
We report a novel, tissue-specific promoter that was identified and engineered from the native upstream regulatory region of the human gene NDUFV1 Cited by: However, a complete map of gene expression in this tissue is lacking. To obtain a gene expression atlas in the wing disc, we employed single cell RNA sequencing (scRNA-seq) and developed a Cited by: 4.
Analysis of this data set revealed that single parent expression (SPE), which is defined as gene expression in only one of the two parents, while commonly observed, is highly genotype- and tissue-specific.
Genes that have SPE in at least one pair of inbreds also tend to be by: 2. Differences in the expression of genes and their splice isoforms across human tissues are fundamental factors to consider for therapeutic target evaluation.
To this end, we conducted a transcriptome-wide survey of tissue-specific gene expression and splicing events in the unprecedented collection of high-quality RNA-seq samples from the GTEx project, covering 36 human Cited by: 2.
Tissue-Specific Proteins Most genes are expressed as proteins. The synthesis within a cell of a particular protein can be detected by antibodies able to bind to that protein.
If the antibodies are coupled to a fluorescent or radioactive tracer, the cells making that protein will reveal themselves. To identify gene co-expression modules enriched with major depression risk genes, we performed gene-set analysis of both (proximity) MAGMA and eMAGMA gene-level results in tissue-specific gene co-expression modules using the gene-sets analysis function in MAGMA vCited by: 5.
Tissue specific metabolism and the metabolic states | Chemical Processes Regulation of Gene Expression: Operons, Epigenetics, and Transcription Factors - Duration: Abstract. Tissue-specific gene expression is critical in understanding biological processes, physiological conditions, and disease.
The identification and appropriate use of tissue-specific genes (TissGenes) will provide important insights into disease mechanisms and organ-specific therapeutic by: Tissue-specific Gene Expression and Regulation (TiGER).
TiGER is a database developed by the Bioinformatics Lab at Wilmer Eye Institute of Johns Hopkins University. The database contains tissue-specific gene expression profiles or expressed sequence tag (EST) data, cis-regulatory module (CRM) data, and combinatorial gene regulation data.